This study is designed to test standard treatment for blood clots with standard treatments and a new treatment. All participants will receive blood-thinning drugs, the standard treatment for blood clots. In addition half of the study participants will be randomly chosen to have their clot dissolved using a clot-busting drug (TPA) that a doctor will inject directly into the clotted vein through a specially designed drug delivery catheter.
Participants are followed for 2 years to assess possible symptoms related to the clot and how well both treatments prevent complications.
The vascular system is the network of blood vessels found throughout the body. Vascular diseases are very common, especially as people age. Many people have these diseases and don't know it, because they rarely cause symptoms in the early stages. Vascular diseases include stroke (a clogged or narrowed blood vessel of the brain), pulmonary embolism (a blood clot breaks loose and travels to the heart and lungs), aneurysms (ballooning of a blood vessel), and peripheral arterial disease (chronic disease effecting arteries of the limbs)
Studies in the vascular field involve treatments and medications for assessment and treatment of the various vascular diseases. Currently enrolling studies in vascular medicine are listed at the right.
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